GDF6 and Anophthalmia: Numerous studies have reported genetic mutations in gdf6 in individuals with anophthalmia, coloboma and extraocular anomalies including cleft palate, absent ossicles, polydactyly and skeletal defects, including Klippel-Feil syndrome, hemivertebrae as well as rib and vertebral fusion [153,154,155,156].