PGR and fatty liver disease: Identified in 1999 using a yeast two-hybrid assay for human B-cell library and the activation function one domain of progesterone receptor as bait, SRA1 is known to affect or regulate a wide variety of physiological and pathological processes including hepatic steatosis, mammary gland development, steroidogenesis, tumorigenesis, stem cell function, myocyte, and adipocyte differentiation [35].