Surprisingly, for FLUAV infection– at least with the chosen H7N7 (SC35M) reporter virus– the observed impact on viral replication was not only much smaller, but IRF3 as well as IRF1 and IRF2 KO slightly but reproducibly (across three replicates) dampened virus replication, while only RIG-I KO clearly rescued it. This evidence concerns the gene RIGI and infection.