This SNP was first described by Oddsson et al. [10] in 237 Icelanders diagnosed with MPN and, although the underlying functional mechanism is still debated, it is thought to (1) directly increase the transcription of TERT, enhancing its expression, and (2) be in linkage disequilibrium with biologically plausible disease-causing mutations. Here, TERT is linked to myeloproliferative neoplasm.