HSP90AA1 and neurodegenerative disease: We also discuss the dicarboxylate clamp mechanism in the interactions of Hsp90 C-terminal Met-Glu-Glu-Val-Asp (MEEVD) peptide and tetratricopeptide repeat (TPR) domain of co-chaperones and provide useful insights for future drug development targeting chaperone/co-chaperone interactions for neurodegenerative diseases.