DYRK1A and Alzheimer disease: Moreover, the client kinases of the Hsp90–Cdc37 chaperone system also include dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), leucine-rich repeat kinase 2 (LRRK2), and PTEN-induced kinase 1 (PINK1), which are involved in AD and PD [33,34,35,36].