In mice, inhibition of the C-X-C motif chemokine receptor (CXCR) 4 (CXCR4) has been previously shown to improve cardiac function post MI [67] and pharmacological CXCR4 blockade promote myocardial repair by increasing Tregs function in vivo [68]. Here, CXCR4 is linked to myocardial infarction.