Another important cell type in the tumor stroma with invasion- and metastasis-promoting capacities are CAFs, mesenchymal cells that, similar to TAMs, are strongly involved in ECM generation and remodeling, regulation of (lymph-) angiogenesis, and the induction of EMT via release of proteases and ECM components, chemokines, TGF-β, and Wnt ligands (reviewed in [101,102]). This evidence concerns the gene TGFB1 and neoplasm.