Using an in vitro model of breast cancer LVI, it was shown that CCID formation was induced by the enzyme arachidonate 15-lipoxygenase (Alox15), which catalyzes the generation of various bioactive lipid mediators including 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) that is chemorepulsive (but not toxic) for LECs [93]. This evidence concerns the gene ALOX15 and breast carcinoma.