For instance, in breast cancer, a combination of inflammatory signals and growth factors induces lymphatic expression of both VCAM-1 and its receptor α4β1 integrin, leading to the reduction of junctional VE-cadherin [79,88], similar to the remodeling of blood endothelial junctions during leukocyte extravasation [89]. The gene discussed is CDH5; the disease is breast carcinoma.