DSG2 and Arrhythmogenic right ventricular dysplasia: To date, 18 ARVC genes have been discovered, with 40% of mutations identified in three major genes, encoding for plakophilin-2 (PKP2), desmoplakin (DSP), and desmoglein-2 (DSG2), which affect desmosomal and area composita proteins, the mechanical cell junctions in the cardiac intercalated disc [5].