Examples of formin levels altering cancer cells is the regulation of microtubule dynamics are the cases of DIAPH1 and DIAPH2, whose silencing impairs chromosome alignment during mitosis in colorectal cancer cell lines, giving rise to aneuploidy, and of DIAPH3, which regulates the activation of the spindle assembly checkpoint and microtubule attachment to kinetochores [174,256,258,330]. Here, DIAPH1 is linked to cancer.