DIAPH1-3 regulate invasion in cell cultures, and reduce metastasis and tumor volume in nude mice inoculated with breast cancer [243,244,245] and glioma [230]; FMNL1 does the same in glioblastoma and clear cell renal cell carcinoma cells [236,281]; FMNL2 [263] and FMNL3 [267] in colorectal cancer cells; FMNL3 in nasopharyngeal carcinoma cells [279]; and FHOD1 in oral squamous carcinoma cells [280]. The gene discussed is FHOD1; the disease is central nervous system cancer.