THBD and Disseminated intravascular coagulation: Most interestingly, thrombomodulin (TM), an endothelial membrane protein, accelerates thrombin-dependent degradation of extracellular HMGB1, an effect being reproduced by recombinant human soluble TM (TMα) that is composed of TM’s extracellular domains and clinically used as a therapeutic agent for disseminated intravascular coagulation (DIC) in Japan [11].