During SARS-CoV-2 infection, the type I interferon (IFN) and IL-6 synthesis are dysregulated in myeloid cells [5,6], resembling the type I IFN signature in systemic lupus erythematosus (SLE) [7,8] and the IL-6-mediated macrophage activation syndrome [9]. Here, IL6 is linked to macrophage activation syndrome.