IGF1 and steatosis: To further isolate the role of hepatocyte GHR signaling from changes in IGF1, aHepGHRkd mice are treated with AAV-TBGp-ratIGF1 that restores circulating IGF1 1evels, sufficient to normalize GH and insulin, but steatosis and liver injury persist [62], further supporting a direct role of hepatocyte GHR signaling in suppressing excess hepatic fat accumulation.