RING-type E3 ubiquitin transferase (RNF6) is known for its ubiquitination of various substrates, including the androgen receptor (AR) [155], transducin-like enhancer of split 3 (TLE3) [156] and the tyrosine phosphatase, SHP-1 [157], in order to mediate the proliferation of various types of cancer cells. Here, TLE3 is linked to cancer.