Alterations in the properties of tau, such as aberrant hyperphosphorylation leading to tau aggregation and assembly into neurofibrillary tangles (NFTs), is characteristic of tauopathies, including Alzheimer’s disease (AD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.