The notion that an increased activation of ATM promotes apoptosis induction by hydroxyurea in PDAC cells is in line with our recent finding that a genetic elimination of the phosphatase-2A subunit PR130 prevents the entinostat-induced dephosphorylation of ATM and that this sensitizes colorectal cancer cells to apoptosis induction by hydroxyurea plus entinostat. The gene discussed is ATM; the disease is colorectal cancer.