PPP2R3A and neoplasm: In other tumor cell types, the cooperative induction of apoptosis by hydroxyurea and HDACi depends on a decrease of the CDKi p21 and p27 [33,35], the reduced expression of the receptor tyrosine kinase EGFR, an increase in the pro-apoptotic BCL2 protein BIM [42], and a breakdown of checkpoint kinase signaling and cell cycle control due to an upregulation of the mRNA and protein expression of the protein phosphatase 2A (PP2A) subunit PR130, which is also known as PPP2R3A [32].