STIM1 and Parkinson disease: A recent work has demonstrated that neurotoxins (i.e., 1-methyl-4-phenylpyridinium ion, MPP+) that mimic PD lead to degeneration of dopaminergic neurons by increasing Ca2+ influx through CaV1.3 channel, by reducing TRPC1 expression, while inhibiting stimulation-dependent STIM1-CaV1.3 interaction [183].