Altogether, these studies demonstrating (i) the identification of NPM-ALK as a potent oncoantigen, (ii) the NPM-ALK-induced escape from immune surveillance, and (iii) the role of autophagy and autophagosomes in tumor antigen presentation and the immune control of tumors strongly advocate for further investigations into how to modulate the autophagic process for the therapeutic success of future ALK+ ALCL immunotherapies. Here, ALK is linked to neoplasm.