In this framework, it is clear that further investigations should be conducted in ALK+ ALCL to determine whether apoptosis or necroptosis could occur secondarily to autophagy in crizotinib-treated cells to ensure lymphoma cells’ full eradication, as observed following ALK and BCL2 or ALK and RAF1 combined inactivation. This evidence concerns the gene BCL2 and anaplastic large cell lymphoma.