The aim of this study was to investigate the irradiation effect on IFNγ-mediated STAT1 and STAT3 phosphorylation and genes expression such as PD-L1 and anti-apoptosis genes in EGFR-positive tumor cells to augment CD8+ T cells cytotoxicity against NSCLC. The gene discussed is STAT1; the disease is non-small cell lung carcinoma.