STAT1 and non-small cell lung carcinoma: Since the previous study has indicated that UV light down-regulates IFNγ-mediated STAT1 phosphorylation [36], therefore we proposed a hypothesis that RT may augment CD8+ T cell-mediated cytotoxicity through blocking IFNs-mediated activations of JAKs-STATs to suppress immunotherapies-resistant EGFR-positive NSCLC.