Among the known miR-296 targets, the Integral membrane protein 2a (Itm2a) inhibits the growth of breast cancer cells through autophagy induction [175,176], while Trp53inp1 (Tumor protein p53-inducible nuclear protein 1) regulates cell stress responses by inducing cell cycle arrest and apoptosis [177,178]. The gene discussed is ITM2A; the disease is breast carcinoma.