CD38 and neoplasm: On the other hand, CD38+ MCs can represent separate subpopulations with their own special properties, which also deserve separate studies using omics technologies, including genomic, transcriptome, proteomic, lipidomic, etc. The more information obtained regarding the multifaceted protein CD38 and MCs in the tumor microenvironment, the more focused the suppression of CD38 activity can be in regard to the efficiency of tumor eradication.