RAF1 and metastatic melanoma: Indeed, two MEK inhibitors (trametinib (GSK) and cobimetinib), either as single agents or together with the RAF inhibitors (vemurafenib (Zelboraf; Genentech/Plexxikon) and dabrafenib (Tafinlar; GlaxoSmithKline)), have been approved for the treatment of patients with metastatic melanoma expressing the mutated RAF paralogue BRAF(V600E) (Figure 1).