Additionally, several cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-12, IL-17A, IL-22, and IL-23, upregulate the production of reactive oxygen species and the hyperproliferative keratinocyte state seen in psoriasis, and are shown to play a role in some malignancies [1]. The gene discussed is IL1B; the disease is psoriasis.