APP and intracerebral hemorrhage: Another study identified that, in intracerebral hemorrhage induced by cerebral amyloid angiopathy, Aβ induced expression and activation of MMP-9 in cerebral vessels of amyloid precursor protein (APP) transgenic mice, and, in postmortem brain tissues of human cerebral amyloid angiopathy (CAA) cases, MMP-9 co-localized with CAA, correlated with the severity of the vascular pathology, and was detected in proximity to microbleeds, suggesting that inhibition of MMP-9 may be a potential preventive strategy for CAA-associated hemorrhage [80].