In a study by Schmidt et al., the authors induced large numbers of CD8 T cells specific for an immunodominant Plasmodium berghei epitope via heterologous prime-boost vaccination with antigen coated DCs and attenuated Listeria monocytogenes expressing the same epitope and managed to induce immunological protection against malaria challenge for at least 19 months [27]. Here, CD8A is linked to malaria.