LEPR and obesity due to melanocortin 4 receptor deficiency: Both the LEPR gene variant (rs1137101) and the BDNF gene variant (rs925946) showed strong association with obesity in the association analysis, as indicated by the beta values (1.068 (0.360; 1.777I), p = 0.003; and 1.237 (0.414; 2.059), p = 0.003, respectively).