In our previous studies we compared the oncotoxicity of VV-GMCSF-Lact and VV-GMCSF-dGF (virus strain without lactaptin) to human tumor cells, including epithelial glioblastoma U87MG, and found that VV-GMCSF-Lact induced the death of all cultured cancer cells more efficiently than recombinant VACV coding only GM-CSF. The gene discussed is CSF2; the disease is cancer.