G9a may also contribute to enhancing breast tumor metastasis by silencing several genes implicated in epithelial-mesenchymal transition (EMT), namely the two anti-metastatic tumor suppressor genes, desmocollin 3 (DSC3), belonging to the cadherin superfamily, and the protease inhibitor MASPIN, which were transcriptionally reactivated in a dose-dependent manner upon inhibition of G9a activity, concomitantly to a significant decrease in global H3K9 dimethylation [130]. This evidence concerns the gene EHMT2 and breast neoplasm.