With regard to medical therapy, the administration of loop-diuretics and mineralocorticoid receptor antagonists was significantly more common among patients with acute HF (p < 0.01), while beta-blockers and inhibitors of the renin–angiotensin–aldosterone system were more prescribed in control patients, as part of the standard therapy in clinically stable HF. The gene discussed is NR3C2; the disease is hydrops fetalis.