ERBB2 and lung cancer: Similarly, in lung cancer, PRMT5 induces the downregulation of tumor suppressor genes, such as GLI pathogenesis related 1 (GLIPR1), leprecan-like 1 (Leprel1), and BTG2, and the upregulation of growth factors such as fibroblast growth factor receptor substrate 1/2/3/4 (FGFR1/2/3/4) and human epidermal growth factor receptor 2/3 (HER2/3), thereby enhancing cell growth [58].