Several studies on rodents demonstrated attenuation of renal fibrosis after injection of BM-MSC-conditioned medium or BM-MSC-derived Evs, through their involvement in inhibiting apoptosis, stimulating tubular epithelial cell proliferation, and decreasing the expression of COLI, αSMA, TGFβ1, TNFα, TIMP-1, MMP-3, and snail family transcriptional repressor 1 (SNAI1) in the kidney [184,185,186,187]. This evidence concerns the gene SNAI1 and renal fibrosis.