SREBF1 and colorectal carcinoma: It was shown that the activity inhibition of Akt and p70S6K kinases in DLD-1 CRC cells significantly attenuate the ACM-increased SREBP-1 mRNA (Figure 3A) and protein (Figure 3B) expressions and ACM-antagonized 5-FU cytotoxicity (Figure 3C) compared to the DMSO- or ad-GFP-pretreated cells.