ABCB1 and osteosarcoma: In addition, the study showed that sEVs from doxorubicin-resistant osteosarcoma cells are likely taken up into auxiliary cells, where they invoke a doxorubicin-resistant phenotype, and multidrug-resistant osteosarcoma cells are able to spread their capacity resist the impact of doxorubicin treatment by exchanging sEVs carrying MDR-1 mRNA and P-glycoprotein [60].