NTRK1 and neoplasm: TEVs can also convert mesenchymal stem cells into myofibroblasts, to enhance tumor metastasis [47]; moreover, sEVs can induce both cell transformation and activation of specific signaling molecules during the process of metastasis, such as the proto-oncogene tyrosine-protein kinase, Src, focal adhesion kinase (FAK), and neurotrophic tyrosine kinase receptor type 1 (TrkA), in recipient cells [48,49].