The five TNF inhibitors (TNFi) used in RA are: infliximab (a chimeric anti-TNFα antibody), adalimumab and golimumab (fully humanized anti-TNFα antibodies), etanercept (a fusion protein linked to the Fc region of human antibody), and certolizumab pegol (a modified human antibody) [5]. The gene discussed is TNF; the disease is rheumatoid arthritis.