It was previously shown that an SET-domain-lacking fragment of the SETD3 gene translocated to the immunoglobulin lambda light chain locus in B-cell lymphomas [44], which resulted in the disruption of the SETD3 gene and appearance of a shorter form of the SETD3 protein lacking the SET domain. This evidence concerns the gene SETD3 and B-cell non-Hodgkin lymphoma.