It is quite conceivable that GRIN2A and GRIN2B, via this DDCS, modulate the activity of the ascending monoaminergic pathways and thus cause the ‘positive’ component of schizophrenia [34], while changes in the prefrontal cortex and hippocampus cause negative and cognitive components to arise [5,6]. Here, GRIN2A is linked to schizophrenia.