ING4 and cancer: ING4 can inhibit the transcriptional activity of nuclear factor NF-κB and hypoxia-inducible factor HIF-1α to inhibit tumor angiogenesis, which has been revealed to have a suppressive role in various cancers, such as lung cancer, hepatocellular carcinoma, glioma, breast cancer, colon cancer, and ovarian carcinoma [5,6].