EPCAM and neoplasm: The authors demonstrated that this system overcame particle aggregation issues, allowed them to achieve high resonance Raman scattering enhancements leading to reproducible high-intensity signals, and allowed multiplex detection and imaging of three important tumor-associated biomarkers (EGFR, EpCAM, or CD44), for discrimination of A431 tumor and 3T3 2.2 nontumor cells with a single excitation laser line.