As was reported, the low-density lipoprotein receptor-related protein 1 (LRP1) is overexpressed in both the brain capillary endothelial cells (BCECs) of BBB and glioblastoma cells and exhibits specific affinity with Angiopep-2 (ANG), which was demonstrated with high efficiency for the crossing of BBB [28,31,32,34,35]. Here, LRP1 is linked to glioblastoma.