The results showed that AuNP-5kPEG-PSMA-1-Pc4 demonstrated an enhanced binding affinity (IC50 = 0.17 nM), this was found to be attributed by the multivalency of AuNPs, a 12-fold increase binding avidity compared to PSMA-1 alone against PSMA expressing prostate tumors; moreover, it was found that internalization was via clathrin-mediated endocytosis [100]. Here, FOLH1 is linked to prostate neoplasm.