We demonstrated that ZNF224 is a mediator of apoptosis induced by ara-C and imatinib acting as a transcriptional co-factor of the Wilms tumor protein 1 (WT1) in the modulation of apoptotic genes and also directly repressing the expression of the oncogenes c-myc and Axl, both of which are involved in oncogenic transformation and drug resistance in CML [24,25,26,27,28]. The gene discussed is ZNF224; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.