Subsequently, employing chromatin immunoprecipitation experiments, luciferase reporter assays and siRNA knockdown of endogenous expression, we demonstrated that ZNF224 acts as a transcriptional co-regulator of WT1, cooperating in the fine-tuning of WT1 apoptotic target genes in chronic myelogenous leukemia (CML) cells and thus exerting a tumor-suppressive role in this hematological malignancy [25,26]. The gene discussed is WT1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.