AKT1 and Familial prostate cancer: Examples involve a synergistic effect of flavonoids from Artocarpus heterophyllus heartwoods on the anti-cancer activity of cisplatin against h460 and mcf-7 cell lines [32], synergistic pro-apoptotic effects of epicatechin in combination with cisplatin in renal tubular carcinoma [33], or quercetin reversing docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways [34].