GSS and Other metabolic disease: This study also demonstrated that aspalathin, isoorientin, and orientin possess some capacity to ameliorate oxidative stress by increasing the gene expression of antioxidant genes such as Sod 1 and Gss in cells treated with antimycin A. An overwhelming number of studies have indeed provided evidence that rooibos and their flavonoids have a great potential that can decrease cellular oxidative damage in various models of metabolic disease, resulting in improved intracellular antioxidant capacity [20,39,40,41].