An inactive form of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) dimers is localized in the cytoplasm by binding to inhibitors of κB (IκB), and after degradation of this inhibitory protein causes translocation (during early stage of infection) of the dimers into the nucleus, NF-κB regulates the expression of numerous genes involved in apoptotic, inflammatory, and immune responses [101]. The gene discussed is NFKB1; the disease is infection.