STAT3 and primary effusion lymphoma: The activity of hTERT promoter and cell proliferation were inhibited by 21, and it decreased the latency-associated nuclear antigen 1 (LANA1), which is essential for segregation, replication, and maintenance of the viral genome, and suppressed STAT3 activity and secretion of pivotal cytokines (IL-6), which plays a role in promoting the survival of KSHV-associated primary effusion lymphoma (PEL) cells [98].