COE (10 or 50 mg/kg/day) reduced memory impairment and neuronal damage caused by 2VO in a mouse model of transient global ischemia; it was suggested that the neuroprotective effects of COE are attributable to its anti-inflammatory properties resulting in decreased expression of inducible nitric oxide synthase (iNOX) and cyclooxygenase-2 (COX-2) and increased expression of the neurotrophic factors pCREB and BDNF [33]. The gene discussed is PTGS2; the disease is memory impairment.