BACE1 and Alzheimer disease: Recently, Shrestha et al. [55] observed anti-AD effects of naphthopyrone and its glycosides including rubrofusarin, rubrofusarin 6-O-β-d-glucopyranoside, rubrofusarin 6-O-β-d-gentiobioside, nor-rubrofusarin 6-O-β-d-glucoside, isorubrofusarin 10-O-β-d-gentiobioside, and rubrofusarin 6-O-β-d-triglucoside by inhibiting AChE, BChE, and BACE1 enzymes.