IL1B and hyperuricemia: The investigation of the nephroprotective role of BRB in a hyperuricemia mice model by Li et al. demonstrated that high BRB doses suppress the expression levels of NLRP3, ASC, caspase1, and IL-1β, thus inhibiting NLRP3 inflammasome activation, which correlated with the significant reduction in pro-inflammatory cytokine (interleukin [IL]-1β and IL-18) levels in serum and the kidney [62].