NLRP3 and Insulin resistance: Further, the effect of BRB in ameliorating insulin resistance by targeting the NLRP3 inflammasome was studied in LPS-primed macrophages stimulated with the palmitate–BSA complex to mimic in vitro adipose tissue macrophages (ATMs) with the activated NLRP3 inflammasome, producing high levels of proinflammatory cytokines.