CB1 is expressed on adipocytes [53].CB1 deletion protects adult mice from diet-induced obesity [21].CB1 increases adipocyte differentiation and adipogenesis [54].CB1 activation increases PPARγ expression, a major regulator of adipose function [52].CB1 enhances fat storage and reduces lipolysis [54,55].CB1 decreases adiponectin production [54,56].CB1 reduces alternative macrophage activation [21]. This evidence concerns the gene CNR1 and obesity due to melanocortin 4 receptor deficiency.