Available literature, predominantly from our group, has reported on the impact of these rooibos bioactive compounds in modulating prime mechanisms involved in the development of insulin resistance and T2D, such as the regulation of phosphoinositide 3-kinase and protein kinase B (Pi3k/Akt) as well as the activation of AMP-activated protein kinase (AMPK) to improve cellular metabolism, through the use of experimental models of metabolic disease [7,9,11,12]. This evidence concerns the gene AKT1 and metabolic disease.