Overall, as a result of the SRM/SIS analysis, 7 out of 28 desired proteins were detected in the blood plasma of LC patients and healthy volunteers: fibronectin (FN1), talin-1 (TLN1), tubulin alpha-4A chain (TUBA4A), heat shock cognate 71 kDa protein (HSPA8), integrin beta-3 (ITGB3), tumor susceptibility gene 101 protein (TSG101), and protein kinase C/casein kinase substrate in neurons protein 2 (PACSIN2). The gene discussed is PACSIN2; the disease is laryngotracheoesophageal cleft.