ITGB3 and laryngotracheoesophageal cleft: In contrast to the unchanged FN1 levels, six other components of the EV proteomic signature (TLN1, TUBA4A, HSPA8, ITGB3, TSG101, and PACSIN2) were upregulated in the LC samples, and TUBA4A, HSPA8, ITGB3, TSG101, and PACSIN2 were exclusively detected in the blood of LC patients.