APOA1 and large cell neuroendocrine carcinoma: Regarding LC, upon applying semi-quantitative SRM assays, retinal dehydrogenase 1 (AL1A1), 4F2hc cell-surface antigen heavy chain (4F2hc/CD98), apolipoprotein A-I (APOA), and β-enolase (ENOB) were found to be upregulated in formalin-fixed paraffin-embedded (FFPE) tissue samples from large-cell neuroendocrine lung carcinoma (LCNEC) patients compared to other lung cancer subtypes [14].