The known role of the RIC-3 protein in α7 nAChR’s maturation, combined with the known roles of α7 nAChR in inflammation and its likely involvement in MS, suggest that genetic variants in the RIC-3 encoding gene (ric3) may affect MS via their effects on α7 nAChR’s maturation in immune cells. The gene discussed is RIC3; the disease is myeloid sarcoma.