This enhanced responsiveness correlated with increased expression of α7 nAChR in PBMCs stimulated with nicotine and PHA in MS patients but not in healthy donors [78] Moreover, treatment of MS patients with IFN-β led to reduced serum levels of pro-inflammatory cytokines and increased serum ACh levels; suggesting that circulating cytokines and ACh are co-regulated [79]. Here, CHRNA7 is linked to myeloid sarcoma.