In patients with diabetes and severe hyperglycemia, many induced metabolic and hemodynamic disorders occur, including the increased development of advanced glycation end products (AGEs), augmented reactive oxygen species (ROS) generation, and initiation of the protein kinase C (PKC) and polyol pathway, which are believed to induce the development and evolution of diabetic nephropathy [39]. The gene discussed is PRRT2; the disease is diabetic kidney disease.