In a randomized double-blind placebo-controlled study, the effects of turmeric on TGF- β, IL-8, and TNF-α levels, as well as proteinuria in the urine and serum, were investigated in patients with T2DM nephropathy (n = 20) and a control group (n = 20). This evidence concerns the gene CXCL8 and type 2 diabetes mellitus.